As well as being a stop-off on the old military trail, the Great Western Cattle Trail had a main water stop near Buffalo at Doby Springs, which was then known as the Buffalo Springs. Surrounded by red earth, deep canyons, and cultivated fields, it presents a wide vista of scenery to travelers and residents alike.

Buffalo's Post Office was established on May 18, 1907, about 5 months before statehood. Brule, located about 3/4 of a mile north of present downtown Buffalo was the first Post Office established in 1899,
but it ceased to exist at statehood when Buffalo became the county seat. Buffalo was nicknamed the "Stone City" because no buildings were permitted in the business district except of "fireproof" construction due to the common prairie fires. Because of this ordinance, many of those buildings are still standing and in use today.